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Large scale characterizations of the tumor immune microenvironment (TIME) across multiple cancer types have consistently revealed at least two kinds of immunosuppressive phenotypes.13 In the first category are tumors characterized by abundant infiltration of myeloid derived suppressor cells and regulatory T-cells (T-regs) often present simultaneously with cytotoxic CD8 +lymphocytes, sometimes referred to as immunologically hot tumors

Pinpointing which of these factors is at play is the key to creating a truly effective treatment plan

3b), but only 5 or the SLC are able to induce Fd secretion (Fig

doi: 10.2147/RRU.S330634 73 MiaoCJWangZJWangXHuangWYGaoXCaoZ

This work was supported by the generous support of the American people through the United States Agency for International Development (USAID)