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At peak demyelination, PEX5cKO DMAMs exhibited increased lipid droplet burden and reduced lipophagy suggestive of impaired lipid catabolism
It is believed that hyperglycemia-related mitochondrial dysfunction leads to pathological changes that promote insulin resistance (IR) as well as type 2 diabetes and the associated organ complications [7]
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We tend to underestimate what it takes to implement meaningful change, which is often as dependent on our environment as it is on our behavior
