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Indeed, BH4 has emerged as a critical regulator of redox homeostasis in macrophages, where loss of GCH1 promotes the accumulation of iNOS-dependent and -independent ROS and impairs NRF2 activation [216]

[20], was used to evaluate MAO activity

Therefore, the present review aims to systematically dissect the core molecular mechanisms of ferroptosis, elucidate its specific pathogenic roles in cognitive disorders including AD, PD and DACI as well as provide a comprehensive overview of emerging diagnostic biomarkers and therapeutic strategies targeting this cell death pathway

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In this context, the onset of AA is characterized by lymphocytic accumulation, while the IFN-mediated positive feedback loop is thought to contribute to the chronicity and progression of the disease (Fig