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For example, in a controlled human 4 h PM 2.5 exposure (to a mean value of 37.8 g/m 3 ), a significant increase occurred in vascular inflammation and acute phase injury markers like serum amyloid A, C-reactive protein, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1

de Sousa G, Langouet S, Nicolas F, Lorenzon G, Placidi M, Rahmani R, et al

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In NSCLC (A549, H1650, H460, H1975, PC-9, H1299, and CCD-19Lu) cells, it inhibits KRAS mutant cell lines by reducing secretory phospholipase A2-IIa (sPLA2-IIa) and NF- B pathway activity, while inhibiting mTOR and AKT while activating AMPK [473]