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The TCA cycle of M2 macrophages has no metabolic flux escape whereas M1 macrophages (treated with LPS) have two points of substrate flux deviation, one occurring at the isocitrate dehydrogenase step reaction and another one at post succinate formation

A significantly higher dose is far more likely to produce a pronounced increase in heart rate and a much warmer flushing sensation

Dimethyl fumarate: a review of preclinical efficacy in models of neurodegenerative diseases