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Second-generation protease inhibitors: simeprevir, faldaprevir, and vaniprevir Simeprevir (TMC435) is an oral, once-daily (QD), HCV NS3/4A macrocyclic protease inhibitor with potent antiviral activity in HCV genotype 1-infected patients as well as HCV genotypes 2, 4, 5 and 6

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Key Takeaways Liposomal encapsulation bypasses saturable transport, enabling up to 4 times higher vitamin C bioavailability

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