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Cai et al (79) evaluated the role of HIF-1 in the acute phase of IPC and suggested that compared with wild-type mice, cardiac function was improved in mice expressing the HIF-1 gene following IPC, and that infarct size and cell death decreased

In this regard, recent research showed that apical liquid dosing in the primary human bronchial epithelial cell/lung fibroblast ALI co-culture model can reprogram gene expression and alter cell physiology, potentially introducing confounding factors that compromise the accuracy of inhaled substance evaluations ( P

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171,172 However, after a six-year follow-up, the application of romidepsin shows beneficial effects in prolonging median progression-free survival

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