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Graphical Abstract 1 Introduction The diagnosis and treatment of cardiovascular disease (CVD) have traditionally focused on the primary clinical syndrome, such as stroke, myocardial infarction (MI), heart failure (HF), or arrhythmias, treating them as isolated disorders affecting either the heart or the brain

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PTX has also been used in humans (in divided doses of 8001600 mg daily) for several inflammatory and fibrotic conditions, including cystic fibrosis, radiation proctitis, radiation pneumonitis, osteoradionecrosis, steatohepatitis, radiation fibrosis, and epidural fibrosis [55,56,57,58]

( C ) Combinations of individual members of SP2 and SP5 were evaluated for TMA production