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Here, the authors show that early-life high-fat/high-sugar diet induces sex-specific alterations in adult feeding behavior, hypothalamic transcriptome and blood metabolome, with Bifidobacterium longum and prebiotic FOS+GOS administration restoring these effects via distinct mechanisms, highlighting their therapeutic potential.

The requirement for GshF can be bypassed by PrfA mutations (PrfA*) that are locked in their active form