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However, as the GLP-1 albumin fusion and unfused albumin have the same theoretical pI, and only small differences in pH-dependent net charge, this probably does not explain the discrepancy between their FcRn binding properties and cellular handling or plasma half-life

Clinical application would require appropriate medical supervision and dosing adjustments

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Expect a staggered outcome: some peptides moving toward legitimate compounding, others staying stuck, and the gray market persisting in the gaps wherever legal access lags demand