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Moran MJ, Zogorski JS, Squillace PJ

In conclusion, GGT and the ChaC family of GSH degrading enzymes, both intracellularly and extracellularly, are key for maintaining GSH homeostasis and serve key roles in normal cellular processes and tumor-related stress conditions

This is particularly relevant in chronic tendinopathy, where the local repair response has stalled

They emphasized that HO-1 functions as an oxidative agonist rather than a driver of ferroptosis, and that ferroptosis occurs only as a secondary event following severe oxidative damage (155)

Experiments were performed to characterize the pharmacokinetics, absorption, distribution, metabolism, and excretion characteristics of BPC157 in rats and dogs
