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we have seen a case attended by discharge of mucus and blood where, after death, the whole internal surface of colon presented a highly vascular, soft, red surface, covered with tenacious mucus or adherent lymph, and here and there a few minute points of ulceration

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Most data derive from controlled experimental models with limited relevance to heterogeneous patient populations, emphasizing the need for biomarker-guided dosing, short-course or localized exposure, and infection-relevant models that assess both microbial clearance and immune competence