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Abstract PROteolysis-Targeting Chimeras (PROTACs) are an emerging class of molecules capable of inducing a forced approximation between a protein of interest (POI) and an E3 ligase enzyme (e.g., Cereblon), leading to the degradation of the POI by the cells own machinery

doi: 10.1046/j.1365-2958.2000.02000.x 275 ScarselliM.SerrutoD.MontanariP.CapecchiB.Adu-BobieJ.VeggiD.et al

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The decisions are made at the insurance level and at the government level