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In cohort 1, 188 patients were allocated (1:1:1:1) to receive once-daily siponimod 10 mg, 2 mg, or 0.5 mg, or placebo for 6 months

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10.1542/peds.2008-0819 [DOI] [PubMed] [Google Scholar] Campbell D

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AGEs crosslinken collageen, waardoor het stijf en bros wordt, een van de hoofdmechanismen van huidveroudering

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All events were mild or moderate in severity with no severe TEAEs reported, and all were resolved

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