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On the one hand, molecular hydrogen is already recognized as a safe component: for example, the US Food and Drug Administration (FDA) has classified H 2 as generally recognized as safe (GRAS) for addition to beverages at concentrations up to ~2% by volume (197)

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For markers lacking physical position information, the coordinates of adjacent genetic markers were used to define the start and end points of the corresponding QTL region

Beyond cellular recognition, the complex interplay among ferroptosis regulatory mechanisms, the immunosuppressive tumor microenvironment, and resistance to immunotherapy represents another critical frontier requiring more profound elucidation