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As secretases are membrane-bound enzymes, their activity can be regulated by the composition of the lipid membranes, and indeed a variety of lipids and of regulators of lipid homeostasis have been shown to influence this process (Haass et al., 2012), is promoted by isoprenoids, diacylglycerol and phospholipase C, while cholesterol, ceramide and sphingosine-1-phosphate promote the activity of -secretase (van der Kant et al., 2019)

Greenlee H, Kwan ML, Kushi LH, Song J, Castillo A, Weltzien E,

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The Slayer therefore consists of approximately 590 000 Slayer subunits, requiring synthesis, export and assembly of 164 subunits per second during exponential growth