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It modulates over 4,000 genes involved in tissue remodeling, suppresses pro-inflammatory cytokines (IL-6, TNF-alpha), and activates proteasome and antioxidant pathways (Pickart et al., BioMed Res Int, 2012)

(801) Gorbach, S

EMT is a primary driver of cancer progression, from early to later aggressive and metastatic stages, and the aggressive growth of many malignancies depends on EMT activation inside tumor cells

Available at: Alayat MSM, et al

For instance, ineffective mitophagy leads to increased ROS production and the accumulation of mitochondrial DNA in the cytoplasm, which enhances the activation of caspase-1 and IL-1