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It can bind directly to the heme iron of NOS to trigger various chemical and biochemical reactions (e.g., NO deoxygenation associated with scavenging of NO and vasoconstriction, as ob- served for hemolytic diseases [ 52 ], or S-nitrosylation of HbA hemoglobin responsible mainly for lung injury associated with an increased formation of red blood cells [ 53 ])

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The fragment is fifteen amino acids long

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Further adjustments for body mass index, hypertension, diabetes mellitus, smoking status, alcohol intake, and history of stroke did not appreciably change these results (RR for all-cause dementia, 0.54 [95% CI, 0.29-0.98