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During sterile inflammation, host-derived DAMPs released by stressed cells contribute to macrophage polarization that aids in resolving sterile inflammation and restores homeostasis (19)

Br J Pharmacol (2020) 177:125877

While anchoring osteoclasts, LPS also activates the TLR4 signaling on the surface of macrophages, prompting the secretion and aggregation of cytokines such as TNF- and IL-6 (77)