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By maintaining NAD + levels, NAPRT helps protect cells from oxidative stress, which is linked to aging and various diseases 225,226
The enzyme transfers a 2C ketol group from xylulose-5-phosphate to ribose-5-phosphate, an aldose
Therefore, targeting the CENPT-GCLC-GSH signaling axis to induce ferroptosis is a promising potential strategy for RCC treatment (Fig

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Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study