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This is caused by an imbalance between factors that relax the endothelium, such as nitric oxide (NO), prostacyclin (PGI 2 ), and down regulation of endothelioum-dependent hyperpolarization (EDH) and factors that cause contraction such as thromboxane A 2 (TxA 2 ) and upregulation of endothelin-1 (ET-1)

Furthermore, the non-invasive measures of LC, such as serological markers of type-III collagen turnover, improved at day 90

The folate-MTHFR-SAM axis supplies the methyl donor required by DNMTs

As the most representative carcinogen in PAHs [8, 42, 124], BaP contributed to breast cancer occurrence by changing tumor suppressor genes methylation

Methylcobalamin has also been found to prevent age-related macular degeneration by supporting the regeneration of retinal cells and protecting against oxidative damage