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doi: 10.5455/medarh.2013.67.79 143 ZieglerDLowPALitchyWJBoultonAJVinikAIFreemanRet al
A4V mutation [edit] A4V (alanine at codon 4 changed to valine) is the most common ALS-causing mutation in the U.S
Samiec, Paula S, Carolyn Drews-Botsch, Elaine W Flagg, Joanne C Kurtz, Paul Sternberg, Robyn L Reed, et Dean P Jones
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The animals were segregated into 4 groups and orally administered pure SIL, GS-16-OPT, GS-12-OPT, or Silybon , each at a dose of 200 mg/kg
