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Proinflammatory cytokines such as Tumor Necrosis Factor (TNF)-, interleukin (IL)-1 or IL-18 induce the endocytosis of epithelial apical junctional proteins [120], promoting an increment in intestinal permeability [121]

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Represents the estimated average level of tax to be paid by the Fund on its annual earnings based on the Funds stated investment strategy, investment profile, current tax legislation and assumes the historical investment and transacting profile will continue