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Moreover, long-term exposure of these AEDs often triggers adverse effects including hepatic injury and renal toxicity, cognitive deficit and psychiatric abnormalities [25]

Multiple advances in the understanding of Nrf2 signaling in brain cancer have emerged, but still a great deal of investigations remains to be performed to determine the specific mechanistic and functional underpinnings of the dual role of Nrf2/Keap1/ARE cascade

doi: 10.1007/s00232-005-0777-0 55 TamuraHSuzukiMMoriyaYHoshinoHOkamotoTYoshidaSet al

Furthermore, only HIIT resulted in a significant increase in HDL-C levels compared to the AS-S group (Fig