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The moderated t-statistics of differential expression was computed by empirical Bayes (eBayes), using a linear model fit (Lmfit) and comparing the overall effect of intervention over control using the following equation: (Intervention.T2Intervention.T1)(Control.T2Control.T1), where T2 is the time point after the 6 weeks of intervention (MV4) and T1 is the time point of the first visit (MV1)

Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor

Oncogenic MYC drives aberrant choline metabolism by transcriptionally upregulating CTP:phosphocholine cytidylyltransferase- ( PCYT1A ) (223), a key enzyme in phosphatidylcholine (PC) de novo biosynthesis