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For example, berberine was found to inhibit cardiac fibroblast proliferation and myofibroblast differentiation by modulating AMPK/PGC-1 signaling, helping to alleviate cardiac fibrosis in models of ischemic or diabetic cardiomyopathy ( Corydalis species) can increase the interaction between PPAR- and NF-B p65, thereby inhibiting NF-B pro-inflammatory signaling and ameliorating cardiac inflammation (Wang M

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