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The authors describe cases where the only visible symptoms were persistent, non-itchy hyperpigmented patches or polymorphic skin lesions

In contrast, pathways typically linked to cellular protection, including MYC targets V1, protein secretion, DNA repair, oxidative phosphorylation, the unfolded protein response, MTORC1 signaling, and adipogenesis, were markedly downregulated (Figure 4B and Supplemental Figure 6A)

According to Cress, an associate professor of nutrition and food science at Wayne State University in Detroit, Michigan, the process begins as soon as we put food in our mouths: 1