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Cytokines derived from M1 macrophages impair tubular autophagy, exacerbating inflammatory injury, whereas M2-mediated fibrosis disrupts vascular architecture, creating hypoxic niches that further drive M2 polarization (55, 56)

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Image credits: Ernst-Gnther Krause (NID)/Pexels (Not the actual photo) Humans have co-evolved with EBV for a long time, so there are still unknowns as far as what happens if you vaccinate against it, Dr