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Research Applications In laboratory research, AMINO-1MQ is investigated for NNMT enzyme inhibition and its downstream effects on NAD+ and S-adenosylmethionine (SAM) metabolism, adipocyte lipogenesis, and energy-expenditure pathways
Whittaker MM, Whittaker JW

Given that APR-246 is a small-molecule drug, it is expected to have off-target, non-p53-dependent effects
Furthermore, MSCs exert an immunomodulatory function by releasing soluble factors as well as via cell-to-cell contact when activated by proinflammatory cytokines [30, 31]

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