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They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost

Further detailed subgroup analyses were conducted with isatuximab in patients with renal impairment, soft-tissue plasmacytomas, and gain(1q21), potentially leading to evidence-based use in patients with these characteristics

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But, the exact dose needed can change based on how severe the deficiency is and how well you respond to treatment