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The critical organelle affected is the mitochondria, whose disruption induces reduction in ATP generation and apoptosis or necrosis [51]
In a specific embodiment, an isolated nucleic acid molecule encodes an antibody that specifically binds to an EphA2 polypeptide, said antibody having the amino acid sequence of 5A8
Moreover, therapeutic strategies aimed at inhibiting the KP can have a dramatic effect on de novo NAD + synthesis [124]
Mutat Res/Genetic Toxicol Environ Mutagenesis 696(1):6980 Saw CLL, Yang AY, Guo Y, Kong A-NT (2013) Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2ARE pathway
However, the authors did not perform specific tests to characterize the phenotype of ferroptosis (232)
