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The ECM can also sequester and locally release growth factors, such as epidermal growth factor (EGF), fibroblast growth factor (FGF) and other signalling molecules (such as WNTs, transforming growth factor- (TGF) and amphiregulin)

Alonso A, Gonzalez-Pardo H, Garrido P, et al

The cagrilintide and semaglutide combination (CagriSema) demonstrated this clearly, with the combination exceeding the sum of individual effects

Optimal therapeutic dose of an agent is identified by acceptable levels of systemic or neurologic toxicity as end points, and efficacy is identified radiologically by monitoring enhancing tumor, a surrogate for tumor volume

V., Vinogradova, D