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The expression of UCP1, a crucial gene involved in thermogenesis, is also enhanced by ectopic expression of PGC-1 , which is critical for BAT thermogenesis [49, 51]

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note in Nature Medicine , NNMT inhibition has been shown to enhance energy expenditure and promote fat loss, even without dietary modification (Kraus et al., Nature Medicine )

Phase 1 activity also surged : An increase from 1,187 (2024) to 1,560 (2025), a 21% year-over-year (YoY) increase, suggests a healthy early-stage pipeline