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In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques Another study published in 2001 found the same thing, yet the results were very different for lean rats versus obese rats: Both hGH and AOD significantly reduced body weight gain in obese mice

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Activity was monitored using fluorescence detection and quantification of the nicotinamide mononucleotide (NMN) reaction product

This rapid, weight-independent improvement in glucose tolerance suggests that disrupting white fat vasculature directly affects metabolic signaling, possibly by interfering with adipokine production or fatty acid metabolism