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Nicotinamide mononucleotide (NMN) is an intermediate of NAD + biosynthesis, result of a reaction between a phosphate group and a nucleoside containing ribose and nicotinamide (NAM) [148]

Genome Biology 24 (1), 159

This poses significant challenges for the long-term success of gene therapy, mainly in patients receiving low doses of AAV, such as children, as tissue growth and proliferation may dilute the vector genome, potentially worsening symptoms over time

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