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A second mechanism that tumour cells employ to evade immune attack is by down-regulating their antigen presenting machinery, including reducing expression of the HLA, -microglobulin and/or peptide transporter genes

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Complex III (cytochrome c reductase/cytochrome bc1 complex) is the central component of the respiratory chain, which transfers electrons from coenzyme Q (transfer from complex I and complex II) to cytochrome c (within complex IV) and contributes to the production of proton gradients (mitochondrial inner membrane)

Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E