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All putative ACO sequences were used to build a phylogenetic tree (see Supplementary Figure 1), which clearly shows a cluster of ancient ACOs within the clade of non-seed land plants and algae

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ChREBP was down-regulated in patients with NAFLD ( n = 22) compared to healthy controls ( n = 10), and instead, SREBP1c was reported to be one of the predominant regulators of DNL in NAFLD, upregulating genes coding for ACC1 and FAS [53]

Prado et al., 2012