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For instance, metformin, a drug used to treat hyperglycemia, triggers AMPK activation through the AMPK-PGC1 pathway in human umbilical vein endothelial cells (HUVECs), leading to reduced mitochondrial ROS levels, the induction of SOD2, and the enhancement of mitochondrial biogenesis, effectively countering hyperglycemia-induced oxidative stress [153]
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It is a small protein made of three amino acids: cysteine, glycine, and glutamate
[DOI] [PMC free article] [PubMed] [Google Scholar] 717.Nearing JT, Comeau AM, Langille MGI
