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DRP-104 is a prodrug of DON that is currently undergoing clinical trials (NCT04471415)
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In KRAS-mutated colon cancer cells, SLC25A22-mediated Gln breakdown reduces H3K4me3 methylation, stimulates the activation of the Wnt/beta-catenin signaling pathway, and diminishes the sensitivity of colon cancer cells to chemotherapeutic agents (35)
Liebner, S., Czupalla, C
Elevation in the level of SOD in sheep liver infected with Fasciola spp
