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Patients were given either 1.5g of MSM, 1.5g of glucosamine, a combination of both, or a placebo for 12 weeks

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3D, E), indicating that combined loss of PHD2 and GSTP1 drives a coordinated, systems-level shift toward growth arrest and cell death that exceeds the effects of either perturbation alone, with potentially lethal consequences for cellular viability

For a detailed description of the above mutations in genes encoding for ion channels and transporters, and additional genetic information provided from KO mouse models, see recent reviews, refs