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The Confidence Tiers We Use in This Review To keep this grounded, each item is labeled by evidence strength and real-world usefulness: Tier 1 (Strong): Consistent benefits across multiple studies and real-world use

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Treatment with DALDA and ibuprofen significantly reduced cold allodynia assessed through the acetone test, and hyperalgesia assessed through the ice floor test, at 0.5, 1, and 2 hours after administration