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Bartlett, M

Incidence of nasal tumours in Wistar rats after 28 months of exposure a,b Types of tumour 0 1350 2700 2760 c mg/m 3 mg/m 3 mg/m 3 mg/m 3 Males Squamous cell carcinoma 1/49 1/52 10/53* 16/49*** Adenocarcinoma 0/49 16/52*** 31/53*** 21/49*** Carcinoma in situ 0/49 0/52 0/53 1/49 Females Squamous cell carcinoma 0/50 0/48 5/53 17/53*** Adenocarcinoma 0/50 6/48* 28/53*** 23/53*** Carcinoma in situ 0/50 0/48 3/53 5/53 a From: Woutersen et al

During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)

Abbreviations GSH: Glutathione PAL: Phenylalanine ammonia-lyase CAD: Cinnamyl alcohol dehydrogenase POD: Peroxidase PG: PGSC0003DMG40 SA: Salicylic acid IAA: Indole-3-acetic acid (auxin) JA: Jasmonic acid qRT-PCR: Quantitative real-time polymerase chain reaction References Liu R, Zhang ZH, Chen SJ, Wang ZH

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