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This disrupts the assembly of the SNARE complex, hindering vesicle docking and reducing dopamine release efficiency [196]

The foundation of effective weight management consists of lifestyle modifications , including: A reduced-calorie, nutritionally balanced diet tailored to individual needs and preferences Regular physical activity, with UK Chief Medical Officers and NHS recommending at least 150 minutes of moderate-intensity aerobic activity per week Behavioural interventions addressing eating patterns, triggers, and psychological factors Long-term support and follow-up to maintain weight loss Pharmacological interventions are considered as adjuncts to lifestyle changes, not replacements

During periods of high physical demand or training