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Lakshmipriya G, Kruthi D, Devarai SK

[21] Under oxidizing conditions, hydrogen sulfide may react with glutathione (or other electrophilic oxidized forms of glutathione) to form glutathione hydropersulfide (GSSH), which is a superior radical-trapping antioxidant and reductant

Antioxidant treatments tend to decrease the epidermal inflammation by inactivating the free radicals and stabilize the membrane and prevent new epidermal destruction.[] PEMPHIGUS VULGARIS In pemphigus vulgaris, increased production of ROS from activated neutrophils has been found to decrease the concentrations of antioxidants in plasma and RBCs, resulting in oxidative stress

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Cheng and Ristow, 2013), steroid hormone biosynthesis, removal of ammonia, integration of metabolic and signaling pathways for cell death and autophagy (Hammerman et al., 2004

VEGF-A from granuloma macrophages regulates granulomatous inflammation by a non-angiogenic pathway during mycobacterial infection