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J Nutr Biochem (2022) 107:109061

Cysteines 8 and 83 are important for GSSG-induced inactivation of GLRX We and others have demonstrated that GLRX can be glutathionylated in association with diminished enzyme activity 8,23

CMAJ 174 937942

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266,267 Excessive ROS levels lead to oxidative damage to DNA, proteins, and lipids, resulting in neuronal apoptosis and impaired nerve function