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Description
The benefits of HIC are clear in the refinement of therapeutic proteins, making HIC essential for both research and biopharmaceutical development

Recent studies have found that a more effective combination of Piperlongumine (PL), CN-A and sulfasalazine (a ferroptosis inducer) significantly promotes ferroptosis in the pancreatic cancer cell lines MIAPaCa-2 and PANC-1 35

In addition, several residues (C670T675) that link the N-terminus of this long -CT helix to the N-terminus of the unliganded -CT interact with the FnIII-1 domain, and serve as an anchor to couple the two -CTs (Fig

Aminopeptidase N Mediates the Utilization of the GSH Precursor CysGly by Cultured Neurons. Journal of Neuroscience Research 66: 10031008

Targeting EZH2 has, therefore, been explored as a potential strategy to overcome drug resistance
