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Renal cortical tubules express the enzyme myo-inositol oxygenase

Post-mortem and imaging studies further reveal deficits in electron transport chain complexes and pyruvate dehydrogenase activity, suggesting a mechanistic link between mitochondrial bioenergetics and ASD-related phenotypes
(1993): Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats
EMBO J 1991 Aug

There's minimal to no downtime required