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Over the past decade, reactive oxygen species (ROS) and free radicals have gained more considerable attention owing to their harmful pathological effects

5 Conclusion and expectations Gut microbiota can be involved in the occurrence and development of many autoimmune diseases through its metabolites, but the study of gut microbiota metabolites in ITP is still in its early stage

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Calcium channel blockers Verapamil inhibits extracellular matrix molecules such as fibronectin and collagen and increases collagenase activity, thereby affecting plaque formation [35, 36]