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Beyond its immune-related roles, tryptophan is involved in hepatic function, specifically in the synthesis of niacin (vitamin B3), which is essential for energy metabolism and DNA synthesis (Bouma et al., Similar to GWS and ME/CFS, disruptions in purine metabolism are suspected to play a role in the pathophysiology of FM

Hard training and modern lifestyles can deplete glutathione, which makes targeted supplementation valuable for athletes and high performers

Moreover, the loss of TXN activity will allow ASK1 to be more readily activated [208211]

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Alternatives depend on the clinical target