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Taking into account the versatile applications of H 2 S, there are attempts to use this mediator as a therapeutic agent

Farhan M, Rizvi A, Aatif M, Muteeb G, Khan K, Siddiqui FA (2024) Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

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Therefore, HIF- 1 undergoes proteasomal degradation due to the presence of PHD2

Lastly, in the advanced stage, collagen becomes heavily cross-linked, and phenotypic changes of fibroblasts to myofibroblasts (MFBs) along with an atrophic epithelium are observed, which increases the risk for epithelial dysplasia and oral squamous cell carcinoma (OSCC) (Passi et al., 2017)